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Meiotic recombination protein Mre11 antibody

Double-strand break repair protein MRE11A
Meiotic recombination 11 homolog 1 (MRE11 homolog 1)
Meiotic recombination 11 homolog A (MRE11 homolog A)
Gene name: MRE11A
The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions.This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity.

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Ref : 00029050

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Product Code pab50001
Immunogen Full length human Mre11 protein.
Target Specificity Reacts with Mre11 from human, mouse, rat, chicken, hamster
Name Meiotic recombination protein Mre11
Uniprot ID P49959
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat, Hamster, Chicken
Labelling None
Appearance Liquid
Form Antiserum
Preservatives NaN3
Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Applications Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry, Flow Cytometry, Immunoprecipitation, Chromatin IP
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IF : 1/200
- IP : 3 µl
- WB : 1/5000
- IHC: 1/10 to 1/200
Print datasheet

ICC/IF : Mre11 antibody <br/>(pab50001)<br/>Anti- Mre11 antibody ICC/IF staining (Green) of Hela cells. . Nuclei (Blue) are counterstained using Hoechst 33258. Antibody pab50001 dilution 1/2000.

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