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MAPK3 / ERK1 (Internal) antibody

Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3
Extracellular signal-regulated kinase 1, ERK-1
Insulin-stimulated MAP2 kinase
MAP kinase isoform p44, p44-MAPK
Microtubule-associated protein 2 kinase
Gene name: MAPK3, ERK1, PRKM3
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.

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Ref : 00018578

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Product Code pab71686
Immunogen Synthetic 20 amino acid peptide from internal region of human MAPK3 / ERK1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%), Mouse, Rat, Bovine (95%)
Target Specificity Reacts with MAPK3 / ERK1 from Human, Gorilla, Gibbon, Monkey. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MAPK1 (70%).
Name MAPK3 / ERK1
Uniprot ID P27361
Gene ID 5595
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Monkey
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.1%
Storage Long term: -70°C; Short term: +4°C
Applications IHC - Paraffin sections
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC-P (4 µg/ml)
Research areas Autophagy
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IHC : MAPK3 / ERK1 (Internal) antibody<br/>(pab71686)<br/>Anti-MAPK3 / ERK1 antibody pab71686 IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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