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L-Caldesmon antibody

Caldesmon, CDM
Gene name: CALD1, CAD, CDM
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration

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Product Code pab0187-P
Immunogen A 15 residue synthetic peptide derived from human L-Caldesmon
Target Specificity Reacts with human L-Caldesmon.
Name L-Caldesmon
Uniprot ID Q05682
Gene ID 800
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC (1:50 - 1:500)
WB (1:200 - 1:5000)
Research areas Cell biology
Print datasheet
* Zheng PP, van der Weiden M, Kros JM. Differential expression of Hela-type caldesmon in tumour neovascularization: a new marker of angiogenic endothelial cells. J Pathol. 2005 Feb,205(3):408-14. (IHC-P)

WB - L-Caldesmon antibody<br/>(pab0187-P)<br/>Anti-L-Caldesmon antibody WB staining of nuclear extracts from breast cancer or glioblastoma

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