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KAT3B/p300 antibody (RW128)

Histone acetyltransferase p300 (p300 HAT)
E1A-associated protein p300
Gene name : EP300, P300
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.

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Product Code mab50128
Clone RW128
Immunogen Fusion protein containing residues 1572-2371 of human p300
Target Specificity Reacts with human p300 protein (residues 1868-1921). Cross reacts with proteins from mouse, rat, monkey and mink.
Name p300
Uniprot ID Q09472
Gene ID 2033
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Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1 / Kappa
Produced in Mouse
Species Human, Mouse, Rat, Monkey, Mink
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents PBS, pH 7.4
Preservatives NaN3 0.1%
Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Applications Western Blot, Immunofluorescence, Immunocytochemistry, Immunoprecipitation
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF 1:10-1:2000,
IP 1:10-1:500,
WB 1:250-1:500
Research areas Cancer,Nuclear signaling,Stem cells
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KAT3B/p300 antibody (RW128)

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