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Hypoxia-inducible factor 2-alpha antibody (ep190b)

Endothelial PAS domain-containing protein 1, EPAS-1
Basic-helix-loop-helix-PAS protein MOP2
Class E basic helix-loop-helix protein 73, bHLHe73
HIF-1-alpha-like factor, HLF
Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha
Member of PAS protein 2
PAS domain-containing protein 2
Gene name: EPAS1, BHLHE73, HIF2A, MOP2, PASD2
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

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Ref : 00028944

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Product Code mab50055
Clone ep190b
Immunogen Human HIF-2 alpha amino acids 535-631
Target Specificity Reacts with HIF-2 alpha from human, mouse hamster and rat. Does not cross-react with HIF-1 alpha.
Name Hypoxia-inducible factor 2-alpha
Uniprot ID Q99814
Gene ID 2034
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Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1
Produced in Mouse
Species Human, Mouse, Rat, Hamster
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Purified (protein G)
Constituents PBS
Preservatives NaN3 0.1%
Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Applications Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry, Flow Cytometry, ELISA, Immunoprecipitation, Chromatin IP
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
ELISA (1:100-1:2000)
FC (1:400)
IHC (1:150-1:300)
WB (1 - 2 µg/ml)
Research areas Angiogenesis,Cancer,Hypoxia,Nuclear signaling
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IHC- HIF-2 alpha antibody (ep190b)<br/>(mab50055)<br/>Anti- HIF-2 alpha antibody IHC staining of heart, cardiac myocytes.

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