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Hypoxia inducible factor-1 alpha antibody (H1alpha67)

Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha)
ARNT-interacting protein
Basic-helix-loop-helix-PAS protein MOP1
Class E basic helix-loop-helix protein 78 (bHLHe78)
Member of PAS protein 1
PAS domain-containing protein 8
Gene name: HIF1A, BHLHE78, MOP1, PASD8
HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes.

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Ref : 00028903

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Product Code mab50049
Clone H1alpha67
Immunogen Fusion protein containing amino acids 432-528 of human HIF-1alpha
Target Specificity Reacts with human HIF-1 alpha. Cross reacts with proteins from monkey, sheep, mouse, rat, rabbit, pig, bovine and ferret.
Name Hypoxia-inducible factor 1-alpha
Uniprot ID Q16665
Gene ID 3091
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Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG2b
Produced in Mouse
Species Human, Mouse, Rat, Monkey, Sheep, Bovine, Porcine, Ferret
Labelling None
Appearance Liquid
Conc. / Activity 1.5 mg/ml
Form Purified (protein A)
Constituents Tris-glycine, 150mM NaCl pH 7.5
Preservatives NaN3 0.05%
Storage Store at 4°C. Do not freeze.
Applications Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry, Flow Cytometry, ELISA, Immunoprecipitation, Chromatin IP, Gel shift
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC 1:100-1:300
WB 1:500-1:1000
ICC/ IF 1:100-1:500
IP 1:10
Research areas Angiogenesis,Cancer,Developmental biology,Hypoxia,Nuclear signaling
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IHC : HIF-1 alpha antibody (H1alpha67)<br/>(mab50049)<br/>Anti- HIF-1 alpha antibody IHC staining of human lung tissue. Antibody mab50049 dilution 1.5 mg/ml.

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