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Hypoxia inducible factor-1 alpha antibody (ESEE122)

Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, HIF-1 α
ARNT-interacting protein
Basic-helix-loop-helix-PAS protein MOP1
Class E basic helix-loop-helix protein 78, bHLHe78
Member of PAS protein 1
PAS domain-containing protein 8
Gene name: HIF1A, BHLHE78, MOP1, PASD8
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters.

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Product Code mab50056
Clone ESEE122
Immunogen Human HIF-1 alpha amino acids 329-530
Target Specificity Reacts with human HIF-1 alpha. Cross reacts with proteins from bovine, mouse and rat.
Name Hypoxia-inducible factor 1-alpha
Uniprot ID Q16665
Gene ID 3091
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Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1
Produced in Mouse
Species Human, Mouse, Rat, Bovine, Canine
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Purified (protein G)
Constituents Tris-glycine, 150 mM NaCl
Preservatives NaN3 0.01%
Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Applications Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry, Immunoprecipitation
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF (10 ug/ml)
IHC (1:100-1:5000)
IP (1:10-1:500)
WB (1:500-1:1000)
Research areas Angiogenesis,Cancer,Nuclear signaling
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IHC - HIF-1 alpha antibody (ESEE122)<br/>(mab50056)<br/>Anti- HIF-1 alpha antibody IHC staining of hypoxia-induced human placenta.

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