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GRP78 / HSPA5 antibody

78 kDa glucose-regulated protein, GRP-78
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein, BiP
Gene name: HSPA5, GRP78
Categorized as stress response proteins, BiPs play an important role in folding and assembly of nascent proteins and in scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5- nontranslated region of BiP mRNA. BiP IRES activity increases when cells are heat-stressed. GRP78 is also important in maintenance of cell homeostasis and the prevention of apoptosis. Levels of GRP78 protein are reduced in brains of Alzheimer’s disease patients.

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Product Code pab74566
Immunogen Recombinant protein encoding full length human HSPA5.
Target Specificity Reacts with human and mouse GRP78.
Name HSPA5 / GRP78
Uniprot ID P11021
Gene ID 3309
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse
Labelling None
Appearance Liquid
Conc. / Activity 0.25 mg/ml
Form Purified (protein G)
Constituents PBS
Preservatives NaN3 0.09%
Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Applications Western Blot, IHC - Paraffin sections, Immunofluorescence, Flow Cytometry
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
FC (1:10 - 1:50)
IF (1:10 - 1:50)
IHC-P (10 µg/ml)
WB (1:1000)
Research areas Autophagy
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IHC - HSPA5 / GRP78 antibody<br/>(pab74566)<br/>Anti-GRP78 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody pab74566 concentration 10 µg/ml.

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