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HIF-1 beta antibody (H1beta234)

Aryl hydrocarbon receptor nuclear translocator
(ARNT protein)
Class E basic helix-loop-helix protein 2 (bHLHe2)
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta (HIF-1-beta), (HIF1-beta)
Gene name: ARNT, BHLHE2
HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits which are bHLH proteins of PAS (PER, ARNT, SIM) family. HIF-1 beta forms heterodimer with AHR, AHRR, HIF1 alpha and EPAS1/HIF2 alpha as well as with other bHLH proteins and its dimerization is required for efficient DNA binding. Interact with TACC3 and NOCA7.

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Ref : 00028910

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Product Code mab50050
Clone H1beta234
Immunogen Fusion protein containing amino acids 496-789 of human HIF-1 beta
Target Specificity Reacts with human HIF 1 beta /ARNT. Cross reacts with proteins from bovine, sheep, mouse, rat and ferret. Not tested in other species.
Name Hypoxia-inducible factor 1-beta
Uniprot ID P27540
Gene ID 405
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Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1 / Kappa
Produced in Mouse
Species Human, Mouse, Rat, Monkey, Sheep, Bovine, Porcine, Ferret
Labelling None
Appearance Liquid
Conc. / Activity 1.4 mg/ml
Form Purified (protein G)
Constituents PBS
Preservatives NaN3 0.05%
Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Applications Western Blot, Immunohistochemistry, IHC - Paraffin sections, Immunoprecipitation, Chromatin IP, Gel shift
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
ChIP 1:10-1:500,
IHC 1:100,
IHC-P 1:100,
WB 1:500
Research areas Angiogenesis,Cancer,Hypoxia,Nuclear signaling
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IHC : HIF-1 beta antibody (H1beta234)<br/>(mab50050)<br/>Anti- HIF-1 beta antibody IHC staining of human glioblastoma multi-forme. Antibody mab50050 dilution 1.4 mg/ml.

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