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Hepatocyte growth factor receptor (HGF receptor) antibody

HGF/SF receptor
Proto-oncogene c-Met
Scatter factor receptor (SF receptor)
Tyrosine-protein kinase Met
Gene name : MET
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.

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Price From: €158.00
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Ref : 00014561

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Product Code pab0596
Immunogen Synthetic peptide derived from Cter domain of human HGF receptor
Target Specificity Reacts with human 155 kDa HGF receptor and cleaved c-Met. Cross reacts with HGF receptor from many species due to sequence homology.
Name Hepatocyte growth factor receptor (HGF receptor)
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Form Antiserum
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/100 to 1/1 000
- WB : 1/1 000 to 1/5 000
Research areas Cancer,Developmental biology,Kinases and phosphatases,Post translational modifications
Print datasheet
Lefebvre J et al.Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity. Cell Death Dis. 2013 Oct 17;4:e871.

Hepatocyte growth factor receptor (HGF receptor) antibody

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