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Heparanase (HPSE) antibody

Endo-glucoronidase
Heparanase-1 (Hpa1)
Gene name : HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Highly selective enzyme cleaving HSPGs at specific intrachain sites. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation.

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Price From: €165.00
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Ref : 00013374

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Product Code pab0232-P
Immunogen Synthetic peptide derived from human N terminal region of Heparanase (HPSE)
Target Specificity Reacts with human 62 kDa HPSE protein, Heparanase 50 kDa subunit and Heparanase 8 kDa subunit. Cross reacts with mouse, rat and bovine protein due to sequence homology.
Name Heparanase (HPSE)
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Rat
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/100 to 1/500
- WB : 1/500 to 1/2 000
Research areas Cancer,Signal transduction
Print datasheet
- Navarro F.P. et al. Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats. J Neurochem. 2008 Apr;105(1):34-45.

Heparanase (HPSE) antibody

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