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GSK3B / GSK3 Beta (C-Terminus) antibody

Glycogen synthase kinase-3 beta, GSK-3 beta
Serine/threonine-protein kinase GSK3B, Gsk 3beta, GSK3 beta, GSK3beta
Gene name: GSK3B
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis.

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Ref : 00026385

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Product Code pab75210
Immunogen Synthetic peptide derived from sequence near the carboxy terminus of human GSK30.
Target Specificity Reacts with the C-terminus part of human GSK3B / GSK3 Beta. Cross reacts with mouse and rat protein. Does not recognize GSK3 alpha.
Name GSK3B / GSK3 Beta
Uniprot ID P49841
Gene ID 2932
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents PBS, pH 7.2, 50% glycerol
Preservatives 0.09% NaN3
Storage +4°C or -20°C, Avoid repeated freezing and thawing.
Applications Western Blot, Immunohistochemistry, IHC - Paraffin sections
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC - P (20 µg/ml), WB (1 µg/ml)
Research areas Autophagy
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IHC : GSK3B / GSK3 Beta (C-Terminus) antibody<br/>(pab75210)<br/>Anti-GSK3B / GSK3 Beta antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody pab75210 conce

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