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Ganglioside-GD3 antibody (4F6)

Ganglioside-GD3 antibody (4F6)

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Product Code mab0014
Clone 4F6
Immunogen Ganglioside-GD3
Target Specificity Reacts with GD3 ganglioside : (NeuAc alpha 2-8NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1Cer). Cross reacts with 9-O-AcGD3 ganglioside (9OAcNeuAc alpha 2-8NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1Cer) and GT1a ganglioside (NeuAc alpha 2-8NeuAc alpha 2-3Gal beta 1-4GalNAc beta 1-4 (NeuAc alpha 2-3) Gal beta 1-4Glc beta 1-1Cer).
Name Ganglioside-GD3
Print datasheet
Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG3 / Kappa
Produced in Mouse
Species All Species
Labelling None
Appearance Lyophilized powder
Form Cell culture supernatant
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications ELISA, Thin-layer chromatography
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA (1:5 - 1:50)
TLC (1:5 - 1:20)
Research areas Cancer,Neurology,Stem cells
Print datasheet
1)Natunen S. et al. Novel acidic glycan markers of human cells. Patent Application publication. 2011 feb 24

2) Kang Y. et al.,Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression.Glycobiology (2006) May:16(5):375-89.

3) Cerato E. et al. Variable region gene segments of nine monoclonal antibodies specific to disialogangliosides (GD2, GD3) and their O-acetylated derivatives. Hybridoma (1997), 16(4), 307-316.

4) Thomas C.P et al. Gangliosides protect human melanoma cells from ionizing radiation-induced clonogenic cell death. Glycoconj. J. (1996), 13(3), 377-384.

5) Zebda N. et al. Deficiency of ganglioside biosynthesis in metastatic human melanoma cells: relevance of CMP-NeuAc:LacCer alpha 2-3 sialyltransferase (GM3 synthase). FEBS Letters (1995), 362(2), 161-164.

6) Portoukalian J. et and al. Shedding of GD2 ganglioside in patients with retinoblastoma. Int. J. Cancer (1993), 53(6), 948-951.

Ganglioside-GD3 antibody (4F6)

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