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Nijmegen breakage syndrome 1 (NBS1) antibody
Nibrin
Cell cycle regulatory protein p95
Nijmegen breakage syndrome protein 1
Gene name: NBN, NBS, NBS1, P95
Cell cycle regulatory protein p95
Nijmegen breakage syndrome protein 1
Gene name: NBN, NBS, NBS1, P95
As low as
€480.40
In stock
Ref
00029052
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex.This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
| ID Covalab | pab50002 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Partial length human NBS1 protein [Swiss-Prot# O60934]. |
| Activity cross reaction | Reacts with NBS1 from human, mouse, hamster and primate. |
| Species | Ham, Hu, Mk, Ms |
| Labelling | None |
| Form | Antiserum |
| Preservative | NaN3 0.02% |
| Storage instructions | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Target | Nijmegen breakage syndrome 1 (NBS1) |
| Uniprot ID | O60934 |
| Applications | ICC, IF, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - ICC : 1/50 to 1/200 - IF : 1/200 - IP : 3 µl - WB : 1/1000 |
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