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E3 ubiquitin-protein ligase HACE1 antibody

HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1
Gene name: HACE1, KIAA1320
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

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Price From: €165.00
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Product Code pab0808-P
Immunogen Synthetic peptide derived from internal domain of human HACE1 protein.
Target Specificity Reacts with human 102 kDa HACE1 protein. Cross react with mouse and Xenopus protein due to sequence homology.
Name E3 ubiquitin-protein ligase HACE1
Uniprot ID Q8IYU2
Gene ID 57531
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Xenopus
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB: 1/1000 to 1/5000
IHC: 1/100 to 1/1000
Research areas Cell cycle,Nuclear signaling,Post translational modifications,Synthesis and degradation
Print datasheet

E3 ubiquitin-protein ligase HACE1 antibody

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