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DNA-(apurinic or apyrimidinic site) lyase (APE-1) antibody

APEX nuclease (APEN)
Apurinic-apyrimidinic endonuclease 1 (AP endonuclease 1), (APE-1)
REF-1
Redox factor-1
Gene name: APEX1, APE, APE1, APEX, APX, HAP1, REF1
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.

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Product Code pab50070
Immunogen Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein
Target Specificity Reacts with human ~37 kDa APE-1 protein. Cross reacts with proteins from mouse, rat and rabbit.
Name DNA-(apurinic or apyrimidinic site) lyase (APE-1)
Uniprot ID P27695
Gene ID 328
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat, Rabbit
Labelling None
Appearance Liquid
Conc. / Activity 0.5 mg/ml
Form Antigen affinity purified
Constituents Tris-glycine, NaCl 150mM buffer
Preservatives NaN3 0.05%
Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Applications Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry, Immunoprecipitation, Chromatin IP, Blocking/Neutralazing
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC: 1/1 000
- WB : 1/1 000
- B/N: 50-200 molar excess
- ChIP: 1/10-1/500
- ICC/IF: 1/50-1/200
- IP: 7 µg/ml
Research areas Cancer,Nuclear signaling
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IHC: APE1 antibody <br/>(pab50070)<br/>Anti-APE1 antibody IHC staining of prostate cancer.

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