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DDIT3 / GADD153 antibody

DNA damage-inducible transcript 3 protein, DDIT-3
C/EBP zeta
C/EBP-homologous protein, CHOP
C/EBP-homologous protein 10, CHOP-10
CCAAT/enhancer-binding protein homologous protein
Growth arrest and DNA damage-inducible protein GADD153
Gene name: DDIT3, CHOP, CHOP10, GADD153
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

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€360.00
Available
Ref : 00026403

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Product Code pab75228
Immunogen Recombinant human GADD153.
Target Specificity Reacts with human, mouse and rat DDIT3 / GADD153.
Name DDIT3 / GADD153
Uniprot ID P35638
Gene ID 1649
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 0.2 mg/ml
Form Purified (protein A)
Constituents PBS, 50% glycerol, 1% BSA
Preservatives 0.02% Thimerosal
Storage +4°C or -20°C, Avoid repeated freezing and thawing.
Applications Western Blot, IHC - Paraffin sections, Immunoprecipitation
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC - P (5 µg/ml)
Print datasheet

IHC - DDIT3 / GADD153 antibody<br/>(pab75228)<br/>Anti-DDIT3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 µg/ml.

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