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CRMP-2 antibody

Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response
mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like
phosphoprotein 2) (ULIP-2) [DPYSL2]
Dihydropyrimidinase-related protein 2 (DRP-2)
N2A3
Unc-33-like phosphoprotein 2 (ULIP-2)
Gene name: DPYSL2, CRMP2, ULIP2
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

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Product Code pab0115
Immunogen A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator
Target Specificity Reacts with human 65 kDa CRMP-2. Cross reacts with mouse and rat proteins. Do not react with CRMP-1, CRMP-3, CRMP-4 or CRMP-5.
Name Collapsing-response mediator protein 2 (CRMP-2)
Uniprot ID Q16555
Gene ID 1808
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Lyophilized powder
Form Antiserum
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
-IHC : 1/500
- WB :1/2 000
Research areas Cytoskeleton,Neurology,Vesicle trafficking
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-Greene N.D. et al. Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. Proteomics. 2007 Apr;7(8):1336-44.
- Veyrac A. et al. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur J Neurosci. 2005;21:2635-48.
-Bertin S. et al. Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol. 2005;486:1-17.
- Quach T. et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol Cell Neurosci. 2004;25:433-43.
- Charrier E. et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system
development and adult neurodegenerative disorders. Mol Neurobiol. 2003;28:51-64. Review.
- Ricard D et al. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin
response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. J Neurosci. 2001 ; 21:7203-14.
- Honnorat J. et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32.

IF: CRMP2 antibody<br/>(pab0115)<br/>Anti-CRPM2 IF staining of olfactory receptors neurons within olfactory mucosa.

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