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CD46 / Membrane cofactor protein antibody (3F1)

TLX
Trophoblast leukocyte common antigen
CD46
Gene name : CD46, MCP, MIC10
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

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Product Code mab0073-P
Clone 3F1
Immunogen Recombinant CD46 protein
Target Specificity Reacts with human 44 kDa CD46 protein. Diffuse and duplicated bands can be seen due to the glycosylation of CD46.
Name CD46 / Membrane cofactor protein
Uniprot ID P15529
Gene ID 4179
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Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1 / Kappa
Produced in Mouse
Species Human
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents PBS
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, IHC - Paraffin sections, Flow Cytometry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA 1:20 000 - 1:100 000
IHC-P 10 µg/ml
WB 1:2000 - 1:10000
Research areas Immunology,Virology
Print datasheet

CD46 / Membrane cofactor protein antibody (3F1)

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