Nucleophosmin (mutant) antibody

Nucleophosmin, NPM
Nucleolar phosphoprotein B23
Nucleolar protein NO38
Numatrin
Gene name: NPM1, NPM
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00096131
Nucleophosmin (NPM) is a multi-functional protein that is involved in many cellular activities including cell growth, proliferation and transformation. It is frequently overexpressed in solid tumors, and has recently been found to be mutated and aberrantly localized in the cytoplasm of leukaemic blasts in patients with acute myeloid leukemia (AML).
More Information
ID Covalab pab50321
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide made to a C-terminal region of human mutant nucleophosmin (within residues 250-294) [AAW67752]
Activity cross reaction Reacts with the mutant form of Nucleophosmin.
Species Hu
Labelling None
Form Antigen affinity purified
Preservative None
Storage instructions Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target Nucleophosmin, mutant
Uniprot ID P06748
Gene ID 4869
Applications FC, IF, IHC - P, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
FC (1:100)
ICC/IF (1:50 - 1:100)
IHC - P (1:50 - 1:100)
IP (1:50)
WB (1:1000)
Publication * Holoubek A. et al. AML-related NPM mutations drive p53 delocalization into the cytoplasm with possible impact on p53-dependent stress response (WB)
* Šašinková M. et al. Sci Rep. 2021 Jan 13:11(1):1084 (WB)
* Šašinková M. Int J Biochem Cell Biol. 2018 Aug 18. pii: S1357-2725(18)30179-1
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