We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Hypoxia-inducible factor 2-alpha antibody (ep190b)
Endothelial PAS domain-containing protein 1, EPAS-1
Basic-helix-loop-helix-PAS protein MOP2
Class E basic helix-loop-helix protein 73, bHLHe73
HIF-1-alpha-like factor, HLF
Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha
Member of PAS protein 2
PAS domain-containing protein 2
Gene name: EPAS1, BHLHE73, HIF2A, MOP2, PASD2
Basic-helix-loop-helix-PAS protein MOP2
Class E basic helix-loop-helix protein 73, bHLHe73
HIF-1-alpha-like factor, HLF
Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha
Member of PAS protein 2
PAS domain-containing protein 2
Gene name: EPAS1, BHLHE73, HIF2A, MOP2, PASD2
As low as
$528.40
In stock
Ref
00028944
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
| ID Covalab | mab50055 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | ep190b |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Human HIF-2 alpha amino acids 535-631 |
| Activity cross reaction | Reacts with HIF-2 alpha from human, mouse hamster and rat. Does not cross-react with HIF-1 alpha. |
| Species | Ham, Hu, Ms, Rat |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | NaN3 0.1% |
| Storage instructions | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Target | Hypoxia-inducible factor 2-alpha |
| Uniprot ID | Q99814 |
| Gene ID | 2034 |
| Applications | ChIP, ELISA, FC, ICC, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: ELISA (1:100-1:2000) FC (1:400) IHC (1:150-1:300) WB (1 - 2 µg/ml) |
Write Your Own Review