LC3A antibody

Microtubule-associated proteins 1A/1B light chain 3B
Autophagy-related protein LC3 B
Autophagy-related ubiquitin-like modifier LC3 B
MAP1 light chain 3-like protein 2
MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B
Microtubule-associated protein 1 light chain 3 beta
Gene name: MAP1LC3B, MAP1ALC3
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00030672
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
More Information
ID Covalab pab50207
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide made to an internal portion of the human LC3A protein sequence (between residues 50-150)
Activity cross reaction Reacts with LC3A from human, mouse, rat, Zebrafish and plants. Predicted to react with Xenopus and bovine based on 100% sequence homology.
Species Hu, Ms, Pl, Rat, Zfi
Labelling None
Form Antigen affinity purified
Preservative NaN3 0.05%
Storage instructions Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Target Light Chain 3A, LC3A
Uniprot ID Q9GZQ8
Gene ID 84557
Applications ICC, IF, IHC - P, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
ICC/IF (1:100-1:300)
IHC (1:200 - 1:400)
IHC-P (1:200 - 1:400)
IP (20 µl / 500 µg of lysate)
WB (2 ug/ml)
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