Hsc70 (Hsp73) (1B5) antibody

Heat shock cognate 71 kDa protein
Heat shock 70 kDa protein 8
Lipopolysaccharide-associated protein 1, LAP-1, LPS-associated protein 1
Gene name: HSPA8, HSC70, HSP73, HSPA10
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00096748
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes
More Information
ID Covalab mab60235
Product type Primary antibodies
Clonality Monoclonal antibody
Clone 1B5
Isotype IgG2a
Raised in Rat
Immunogen Hsc70 purified from sodium arsenite treated heat-resistant variants of Chinese hamster cells.
Activity cross reaction Reacts with human Hsc70 (Hsp73). Cross-reacts with mouse, rat, rabbit, guinea pig, hamster, monkey, sheep, chicken, bovine, canine and porcine protein.
Species Chick, Hu, Ma, Ms, Rat
Labelling None
Form Purified (protein G)
Preservative None
Storage instructions Store frozen product at or below -20°C.
Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot and store at -20°C.
Target Hsc70 (Hsp73)
Uniprot ID P11142
Gene ID 3312
Applications ICC, IHC, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
WB (0.1 µg/ml)
IP (5 µg/ml )
IHC (5 µg/ml)
ICC ( 5 µg/ml)
Positive control HeLa Heat Shocked Cell Lysate
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