Retinal-specific ATP-binding cassette transporter antibody

Retinal-specific ATP-binding cassette transporter
ATP-binding cassette sub-family A member 4
RIM ABC transporter (RIM protein) (RmP)
Stargardt disease protein
Gene name : ABCA4, ABCR
As low as $323.40
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00028953
Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) .
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
More Information
ID Covalab pab0887-P
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide derived from internal domain of human ABCA4 protein.
Activity cross reaction Reacts with human ABCA4 protein.
Species Hu
Labelling None
Form Purified (protein A)
Preservative None
Storage instructions Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target Retinal-specific ATP-binding cassette transporter
Uniprot ID P78363
Applications ELISA, IHC, WB
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only :
- WB : 1 to 5 µg/ml
- IHC : 1/100 to 1/1000
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