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NEDD4-like E3 ubiquitin-protein ligase WWP1 antibody
Atrophin-1-interacting protein 5 (AIP5)
TGIF-interacting ubiquitin ligase 1 (Tiul1)
WW domain-containing protein 1
Gene name : WWP1
TGIF-interacting ubiquitin ligase 1 (Tiul1)
WW domain-containing protein 1
Gene name : WWP1
As low as
$323.40
In stock
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00013572
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF
| ID Covalab | pab0879-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from internal part of human WWP1 protein |
| Activity cross reaction | Reacts with human WWP1 protein. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | NEDD4-like E3 ubiquitin-protein ligase WWP1 |
| Uniprot ID | Q9H0M0 |
| Applications | ELISA, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only : WB (1:200 - 1:2000) |
| Publication | * Zaarour RF et al. Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity. PLoS One. 2012,7(5):e37490. |
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