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BACE1 (pSer498) antibody

Beta-secretase 1
Aspartyl protease 2 (ASP2) (Asp 2)
Beta-site amyloid precursor protein cleaving enzyme 1 (Beta-site APP cleaving enzyme 1)
Membrane-associated aspartic protease 2
BACE1, BACE, KIAA1149, APP beta-secretase, ASP2, Aspartylprotease 2, B-Secretase, Beta-site app cleaving enzyme, FLJ90568, HSPC104
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

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Product Code pab70382
Immunogen KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE.
Target Specificity Reacts with human BACE1
Name BACE1
Accession Number P56817
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Liquid
Conc. / Activity 0.25 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.09%
Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Applications Western Blot, IHC - Paraffin sections, ELISA
Working dilutions ELISA (1:50 - 1:100), IHC - P (5 µg/ml), WB (1:100 - 1:500)
Research areas Neurology,Signal transduction,Vesicle trafficking
Print datasheet

IHC : BACE1 (pSer498) antibody<br/>(pab70382)<br/>Anti-BACE1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 µg/ml.

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