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BACE1 (N-Terminus) antibody

Beta-secretase 1
Aspartyl protease 2 (ASP2) (Asp 2)
Beta-site amyloid precursor protein cleaving enzyme 1 (Beta-site APP cleaving enzyme 1)
Membrane-associated aspartic protease 2
BACE1, BACE, KIAA1149, APP beta-secretase, ASP2, Aspartylprotease 2, B-Secretase, Beta-site app cleaving enzyme, FLJ90568, HSPC104
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

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Product Code pab70380
Immunogen Synthetic 18 amino acid peptide from near N-terminus of human BACE1. Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Monkey (100%), Marmoset (100%), Rat (100%), Mouse (94%), Bovine (94%), Hamster (9 ...
Target Specificity Reacts with human BACE1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ZBTB47 (44%).
Name BACE1
Uniprot ID P56817
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.1%
Storage Long term: -70°C, Short term: +4°C
Applications IHC - Paraffin sections
Working dilutions IHC - P (2.5 µg/ml)
Research areas Neurology,Signal transduction,Vesicle trafficking
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IHC : BACE1 (N-Terminus) antibody<br/>(pab70380)<br/>Anti-BACE1 antibody IHC of human brain, Alzheimer's. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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