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ASAH2 (C-Terminus) antibody

Neutral ceramidase (N-CDase) (NCDase)
Acylsphingosine deacylase 2
LCDase (hCD)
N-acylsphingosine amidohydrolase 2
Non-lysosomal ceramidase
ASAH2, BCDase, HNAC1, MGC129777, Mitochondrial ceramidase
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract

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Ref : 00015819

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Product Code pab70348
Immunogen 17 amino acid peptide near the carboxy terminus of the human ASAH2.
Target Specificity Reacts with ASAH2 from human, mouse and rat
Name ASAH2
Accession Number Q9NR71
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Applications Western Blot, IHC - Paraffin sections
Working dilutions IHC - P (5 µg/ml), WB (1 µg/ml)
Research areas Apoptosis,Cell metabolism,Lipidomics
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IHC : ASAH2 (C-Terminus) antibody<br/>(pab70348)<br/>Anti-ASAH2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 µg/ml.

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