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APP (pThr668) antibody

Amyloid beta A4 protein
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide (CVAP)
Protease nexin-II (PN-II)
AAA, ABETA, ABPP, AD1, Alzheimer's disease amyloid a4 protein, Amyloid beta, Amyloid beta A4 precursor protein, Amyloid beta peptide, Amyloid beta precursor protein, Beta amyloid, CTFgamma, CVAP, PN2
Defects in APP are the cause of Alzheimer disease type 1 (AD1).
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity

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Ref : 00019331

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Product Code pab72058
Immunogen Synthetic peptide from human APP containing a phosphoThr at position 668.
Target Specificity Reacts with human APP (pThr 668). Cross reacts with mouse and rat protein.
Name APP
Accession Number P05067
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Product type Primary antibodies
Clonality Polyclonal antibody
Isotype IgG
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS, glycerol 50%
Preservatives NaN3 0.02%
Storage +4°C or -20°C, Avoid repeated freezing and thawing.
Applications Western Blot, IHC - Paraffin sections
Working dilutions IHC-P (10 µg/ml), WB
Research areas Apoptosis,Disease-related biomarkers,Neurology,Vesicle trafficking
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IHC : APP (pThr668) antibody<br/>(pab72058)<br/>Anti-APP antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 µg/ml.

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