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APP (aa737-751) antibody

Amyloid beta A4 protein
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide (CVAP)
Protease nexin-II (PN-II)
APP, AAA, ABETA, ABPP, AD1, Alzheimer's disease amyloid A4 protein, Amyloid beta peptide, Amyloid beta precursor protein, APPI, Beta amyloid, CTFgamma, CVAP, PN2
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP.
Implicated in Notch signaling pathway

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Ref : 00015805

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Product Code pab70334
Immunogen Synthetic peptide from human APP.
Target Specificity Reacts with peptide corresponding to amino acids 737 to 751 of human amyloid A4 protein precursor (APP) or 85 to 99 of the C99 fragment generated by b-secretase cleavage. May cross react with monkey, mouse, rat, chicken, and a variety of other species due to sequence homology.
Name APP
Accession Number P05067
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 0.5 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Applications Western Blot, Immunohistochemistry, IHC - Paraffin sections
Working dilutions IHC (2 µg/ml), IHC - P (5 µg/ml), WB (2 µg/ml)
Research areas Apoptosis,Disease-related biomarkers,Neurology,Vesicle trafficking
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IHC :APP (aa737-751) antibody<br/>(pab70334)<br/>Anti-APP antibody IHC of human brain, cortex, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 µg/ml.

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