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APH1A (N-Terminus) antibody

Gamma-secretase subunit APH-1A (APH-1a)
Aph-1alpha
Presenilin-stabilization factor
APH1A, 6530402N02Rik, APH-1, APH-1A, CGI-78
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Belongs to the APH-1 family. Implicated in Notch signaling pathway.

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€360.00
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Ref : 00015804

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Product Code pab70333
Immunogen Synthetic peptide from human APH1A.
Target Specificity Reacts with 13 amino acid peptide from near the amino terminus of human APH1a.
Name APH1A
Accession Number Q96BI3
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Applications Western Blot, IHC - Paraffin sections
Working dilutions IHC - P (3, 2.5 µg/ml), WB
Research areas Apoptosis,Neurology,Vesicle trafficking
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IHC : APH1A (N-Terminus) antibody<br/>(pab70333)<br/>Anti-APH1A antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 µg/ml.

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