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Angiotensinogen antibody

Angiotensinogen
Serpin A8
Gene name: AGT, SERPINA8
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.

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Product Code pab0624-P
Immunogen Synthetic peptide derived from Nter domain of human Serpin A8 protein
Target Specificity Reacts with human 53 kDa AGT protein. Cross reacts with the proteins from mouse, rat and other species due to sequence homology.
Name Angiotensinogen (AGT)
Uniprot ID P01019
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user
The following are guidelines only :
- IHC : 1/50 to 1/500
- WB : 1/200 to 1/2 000
Research areas Cardiac and vascular biomarkers,Cell biology
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Angiotensinogen antibody

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