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Alpha-actinin-4 (ACTN4) antibody

F-actin cross-linking protein
Non-muscle alpha-actinin 4
Gene name: ACTN4
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions.

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Price From: €165.00
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Ref : 00013218

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Product Code pab0221-P
Immunogen Synthetic peptide derived from N- term domain of the human ACTN4 protein.
Target Specificity Reacts with human 110 kDa of ACTN4 protein. Cross reacts with rat and mouse protein due to sequence homology.
Name Alpha-actinin-4 (ACTN4)
Uniprot ID O43707
Gene ID 81
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/100 to 1/500
- WB : 1/500 to 1/2 000
Research areas Cancer,Cell biology,Signal transduction
Print datasheet
- Celli L. et al. Evidence of a Functional Role for Interaction between ICAM-1 and Nonmuscle -Actinins in Leukocyte Diapedesis. The Journal of Immunology; 2006, 177: 4113-4121.

Alpha-actinin-4 (ACTN4) antibody

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