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ALIX antibody (8E8)

Programmed cell death 6-interacting protein
PDCD6-interacting protein
ALG-2-interacting protein 1
ALG-2 interacting Protein-X
Hp95
Gene name: PDCD6IP, AIP1, ALIX, KIAA1375
Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).

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Product Code mab0083-P
Clone 8E8
Immunogen Purified recombinant human ALIX protein
Target Specificity Reacts with human ALIX protein.
Name ALIX
Uniprot ID Q8WUM4
Gene ID 10015
Print datasheet
Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1 / Kappa
Produced in Mouse
Species Human
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB (1:200 - 1:1000)
IHC (1:100 - 1:500)
Research areas Apoptosis,Autophagy,Cell cycle,Cytoskeleton,Vesicle trafficking,Virology
Print datasheet

WB - ALIX antibody (8E8)<br/>(mab0083-P)<br/>Anti-ALIX antibody WB staining of 10 µg (lane 1) and 100 µg (lane 2) of recombinant GST-ALIX.

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