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AIRE (Internal) antibody

Autoimmune regulator
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein (APECED protein)
AIRE, AIRE1, APECED, Apeced protein, APS1, APSI, PGA1
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes

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Ref : 00019415

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Product Code pab72142
Immunogen Synthetic peptide C-KDVDLSQPRKGRKP from an internal region of human AIRE (NP_000374.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Rat (100%), Horse (100%), Dog (100%), Hamster (100%), Elephant (100%)
Target Specificity Reacts with human AIRE. This antibody is expected to recognise isoform 1 (NP_000374.1) only. Cross reacts with bovine, canine and rat protein.
Accession Number O43918
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Goat
Species Human, Rat, Bovine, Canine
Labelling None
Appearance Liquid
Conc. / Activity 0.5 mg/ml
Form Antigen affinity purified
Constituents TBS, pH 7.3, BSA 0.5%
Preservatives NaN3 0.02%
Storage Store at -20°C. Minimize freezing and thawing.
Applications Western Blot, IHC - Paraffin sections, ELISA
Working dilutions ELISA (1:32000), IHC-P (2.5 µg/ml), WB (0.5 - 1 µg/ml)
Research areas Cytoskeleton,Immunology,Nuclear signaling
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IHC : AIRE (Internal) antibody<br/>(pab72142)<br/>Anti-AIRE antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 µg/ml.

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