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AGT / Angiotensinogen (Internal) antibody

Angiotensinogen
Serpin A8
Gene name: AGT, SERPINA8
ANHU, FLJ92595, FLJ97926
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.

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€360.00
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Product Code pab70296
Immunogen Synthetic 12 amino acid peptide from internal region of human AGT / Angiotensinogen. Percent identity with other species by BLAST analysis: Human (100%), Chimpanzee (100%), Gorilla (100%), Orangutan (100%), Gibbon (100%), Monkey (100%), Marmoset (100%).
Target Specificity Reacts with human AGT / Angiotensinogen. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Name AGT / Angiotensinogen
Accession Number P01019
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.1%
Storage Long term: -70°C; Short term: +4°C
Applications IHC - Paraffin sections
Working dilutions IHC - P (2.5 - 5 µg/ml)
Research areas Cardiac and vascular biomarkers,Cell biology
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IHC : AGT / Angiotensinogen (Internal) antibody<br/>(pab70296)<br/>Anti-AGT / Angiotensinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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