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ADAMTS4 (Metalloprotease Domain) antibody

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4)
Gene name : ADAMTS4, KIAA0688
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

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Ref : 00015651

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Product Code pab70258
Immunogen Synthetic 16 amino acid peptide from Metalloprotease domain of human ADAMTS4. Percent identity with other species by BLAST analysis: Human (100%), Orangutan (100%), Gibbon (100%), Marmoset (100%), Panda (100%), Dog (100%), Bat (100%), Horse (100%)
Target Specificity Reacts with human ADAMTS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Accession Number O75173
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.1%
Storage Long term: -70°C; Short term: +4°C
Applications IHC - Paraffin sections
Working dilutions IHC - P (4 )
Research areas Disease-related biomarkers,Inflammation
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IHC : ADAMTS4 (Metalloprotease Domain) antibody<br/>(pab70258)<br/>Anti-ADAMTS4 antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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