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Ambra1 antibody

Activating molecule in BECN1-regulated autophagy protein 1
Gene name: Ambra1, Kiaa1736
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation

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Price From: €165.00
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Product Code pab0224-P
Immunogen Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein.
Target Specificity Reacts with mouse 120 kDa Ambra1 protein. Cross reacts with human and rat protein.
Name Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1)
Uniprot ID Q9C0C7
Gene ID 55626
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA, Immunoprecipitation
Working dilutions Optimal dilution should be determined by the end user.
Research areas Autophagy,Neurology
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Pagliarini V et al. Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response. Cell Death Differ. 2012 Mar 23.

Paronetto M.P et al. Peptidic and peptidometic compound for regulating autophagy. US Patent Application. 2011 Nov : 20110281804.

Armstrong J.L. et al. Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition. Clin Cancer Res. 2011 Apr 15,17(8):2216-26.

Di Bartolomeo S.et al. The dynamic interaction of AMBRA1 With the dynein motor complew regulates mamalian autophagy. J Cell Biol. 2010 Oct 4,191(1):155-68.

Fimia G.M. et al. Ambra-1 regulates autophagy and development of the nervous system. Nature. 2007 Jun 28,447(7148):1121-5.

IF: Ambra1 antibody<br/>(pab0224-P)<br/>Anti-Ambra1 antibody IF staining of human fibroblasts expressing full length Ambra1.

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