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AAK1 (N-Terminus) antibody

AP2-associated protein kinase 1
Adaptor-associated kinase 1
AAK1, Adaptor-associated kinase 1, DKFZp686F03202, DKFZp686K16132, FLJ23712, FLJ25931, FLJ31060, FLJ42882, FLJ45252, KIAA1048, MGC138170, MGC164568, MGC164570
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

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€360.00
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Ref : 00015621

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Product Code pab70228
Immunogen Aak1 antibody was raised against a 20 amino acid peptide near the amino terminus of the human Aak1.
Target Specificity Reacts with human Aak1. Cross reacts with proteins from mouse and rat.
Name AAK1
Accession Number Q2M2I8
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Applications Western Blot, IHC - Paraffin sections, Immunocytochemistry
Working dilutions ICC, IHC - P (5 µg/ml), WB (1 - 2 µg/ml)
Research areas Kinases and phosphatases,Post translational modifications
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IHC : AAK1 (N-Terminus) antibody<br/>(pab70228)<br/>Anti-AAK1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 µg/ml.

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