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A2M / Alpha-2-Macroglobulin (C-Terminus) antibody

Alpha-2-macroglobulin (Alpha-2-M)
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
A2M, CPAMD5, DKFZp779B086, FWP007, S863-7
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

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orders@covalab.com - tel: +33 (0) 437 654 230 - fax: +33 (0) 437 289 416

€360.00
Available
Ref : 00020312

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Product Code pab72635
Immunogen Synthetic peptide from human A2M / Alpha-2-Macroglobulin.
Target Specificity Reacts with the C-terminus part of human A2M / Alpha-2-Macroglobulin. Cross reacts with rat protein.
Name A2M / Alpha-2-Macroglobulin
Accession Number P01023
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Rat
Labelling None
Appearance Liquid
Conc. / Activity 0.5 mg/ml
Form Antigen affinity purified
Constituents PBS, glycerol 50%
Preservatives NaN3 0.01%
Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Applications Western Blot, IHC - Paraffin sections, ELISA
Working dilutions ELISA, IHC-P (10 µg/ml), WB (1 µg/ml)
Research areas Cardiac and vascular biomarkers,Signal transduction
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IHC : A2M / Alpha-2-Macroglobulin (C-Terminus) antibody<br/>(pab72635)<br/>Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concen

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