chemical modifications for peptide synthesis

After synthesis has occurred, peptides can undergo chemical modifications in order to either mimic natural post-translational modification or be used in specific applications (e.g. protein structure or function analysis). If you don't find the modification you are looking for, feel free to contact us for more informations.

Radioisotope labelled residues

15N Ala
15N Arg
15N Asp
15N Gln
15N Glu
15N Gly
15N Ile
15N Leu
15N Lys
15N Phe
15N Pro
15N Thr
15N Tyr
15N Val
Others (please contact us)

Fatty acid addition (N-terminus)

Hexanoic acid C6
Octanoic acid C8
Decanoic acid C10
Lauric acid C12
Myristic acid C14
Palmitic acid C16
Stearic acid C18
Perfluoro Octanoic acid F15C8
Perfluoro Decanoic acid F19C10
Perfluoro Lauric acid F23C12
Perfluoro Myristic acid F27C14

Functional group addition (N-terminus)

(H-) Free amino group
3-Mercaptopropyl
9-Fluorenylmethyloxycarbonyl
Acetyl
Acryl
Allyl
Allyloxycarbonyl
Benzoyl (BZ)
Benzyloxycarbonyl (CBZ)
Bromoacetyl
Formyl
Hydroxyphenylpropionic acid
Lipoic acid
Maleimide, Maleoyl-β-Ala
Methotrexate
Pyroglutamyl
Succinyl
Tertbutoxycarbonyl (Boc)

Functional group addition (C-terminus)

(OH-) Free carboxylic acid group
7-amino-4-methylcoumarin
Alcohol (-OH)
Aldehyde (-CHO)
Amide
Chloromethylketone
Cysteamide
Fluoromethylketone
Hydroxysuccinimide ester
p-Nitroaniline
Para-nitrophenol
Methyl ester
Ethyl ester
Benzyl ester
Tertiobutyl ester
Tertiobenzyl ester
Methylamin
Ethylamin

Phosphorylation

pSer
pThr
pTyr
D-pSer
D-pThr
D-pTyr
2-sites in sequence
3-sites in sequence
4-sites in sequence
5-sites in sequence

Atom linker

2 atoms (Gly)
3 atoms (β-Ala)
4 atoms (GABA)
5 atoms (Ava)
6 atoms (Ahx)
9 atoms (Mini-PEG, AEEA)
13 atoms (Mini-PEG2, AEEEP)
16 atoms (Mini-PEG3, AEEEEP)

Fluorescence / Dye labelling (N-terminus)

3-Indolylacetic acid
5-FAM
5-FAM (via side chain of Lys)
5-FAM-LC
Biotin
Biotin (via side chain of Lys)
Biotin-LC
Cys (Npys)
D-Luciferin
Dansyl
Dansyl (via side chain of Lys)
Dansyl-LC
FITC
FITC (via side chain of Lys)
FITC-LC
MCA
PyBA-, 1-pyrenebutyric acid
TMR
TMR (via side chain of Lys)

Fluorescence / Dye labelling (Internal)

5-FAM (via side chain of Lys)
Biotin (via side chain of Lys)
Dab (Dnp)
Dansyl (via side chain of Lys)
Dap (Dnp), Dpa
Dnp (via side chain of D-Lys)
Dnp (via side chain of Lys)
FITC (via side chain of Lys)
TMR (via side chain of Lys)

Fluorescence / Dye labelling (C-terminus)

5-FAM (via side chain of Lys)
Biotin (via side chain of Lys)
Dab (Dnp)
Dansyl (via side chain of Lys)
Dap (Dnp), Dpa
Dnp (via side chain of D-Lys)
EDBiotin
EDDnp
FITC (via side chain of Lys)
TMR (via side chain of Lys)

Quenched fluorescent peptide

Abz / Tyr (3-NO2)
Abz
DABCYL
DABCYL / Glu (EDANS)-NH2
Glu (EDANS)-NH2
Tyr (3-NO2)

MAPS and Carrier Complex

Asymmetric 2 branches (Pure)
Asymmetric 4 branches (Crude)
Asymmetric 8 branches (Crude)
n-mer branch peptide on Lys side chain
n-mer branch peptide on Ser side chain
n-mer branch peptide on Thr side chain
Alkine (via side chain of Lys)
Glu 2 branches (Pure)
Glycerol 3 branches
Maleimide (via side chain of Lys)
Methylmalonyl (via side chain of Lys)
MTX (via side chain of Lys)
Pal (via side chain of Lys)
Suc (via side chain of Lys)
BSA-Peptide
KLH-Peptide
OVA-Peptide

Cyclisation

Cyclisation via amide group (end)
Cyclisation via amide group (side chain)
Cyclisation via thioester group
Disulfide bond (simple)
Disulfide bond (double)
Disulfide bond (triple)
Inter-Disulfide bond (Same Sequence)
Inter-Disulfide bond (Different)

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